June 2018 MA

Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature H GCSE BIOLOGY Higher Tier Paper 1H Tuesday 15 May 2018 Afternoon Time allowed: 1 h ou r 45 minutes Materials For Examiner’s Use For this paper you must have: Question Mark • a ruler 1 • a scientific calculator . 2 Instructions 3 • Use black ink or black ball - point pen. 4 • Fill in the boxes at the top of this page. 5 • Answer all questions in the spaces provided. • Do all rough work in this book. Cross through any work you do not want 6 to be marked. 7 • In all calculations, show clearly how you work out your answer. TOTAL Information • There are 100 marks available on this paper. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. * JUN18 84611H01 * 8461/1H IB/M/Jun18/E 8

Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature H GCSE BIOLOGY Higher Tier Paper 1H Tuesday 15 May 2018 Afternoon Time allowed: 1 h ou r 45 minutes Materials For Examiner’s Use For this paper you must have: Question Mark • a ruler 1 • a scientific calculator . 2 Instructions 3 • Use black ink or black ball - point pen. 4 • Fill in the boxes at the top of this page. • Answer all questions in the spaces provided. 5 • Do all rough work in this book. Cross through any work you do not want 6 to be marked. 7 • In all calculations, show clearly how you work out your answer. TOTAL Information • There are 100 marks available on this paper. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. * JUN18 84611H01 * 8461/1H IB/M/Jun18/E 8

2 Do not write outside the box There are no questions printed on this page DO NOT WRITE ON THIS PAGE ANSWER IN THE SPACES PROVIDED * 02 * IB/M/Jun18/8461/1H

2 Do not write outside the box There are no questions printed on this page DO NOT WRITE ON THIS PAGE ANSWER IN THE SPACES PROVIDED * 02 * IB/M/Jun18/8461/1H

3 Do not write - outside the 0 1 Eating food containing Salmonella bacteria can cause illness . box 0 1 . 1 Two symptoms of infection by Salmonella are vomiting and diarrhoea. What causes these symptoms? [1 mark] l toxins 0 1 . 2 Give two ways a person with a mild infection of Salmonella can help prevent the spread of the bacteria to other people. [2 marks] 1 wash hands after being sick Isolation - 2 Avoid food Isolate infected person preparing - if 1 , 0 1 . 3 In very serious infections of Salmonella , a doctor can prescribe drugs to kill the bacteria. - What type of drug can the doctor prescribe to kill the bacteria? [1 mark] Antibiotics I acquired immunodeficiency syndrome § gy ← 0 1 . 4 A person with AIDS may take longer than a healthy person to recover from a Salmonella infection. Explain why. [2 marks] Immune system damaged / weaker is and white blood , healthy cells cannot kill Salmonella effectively as as in a person . Turn over ► * 03 * IB/M/Jun18/8461/1H

3 Do not write - outside the 0 1 Eating food containing Salmonella bacteria can cause illness . box 0 1 . 1 Two symptoms of infection by Salmonella are vomiting and diarrhoea. What causes these symptoms? [1 mark] l toxins 0 1 . 2 Give two ways a person with a mild infection of Salmonella can help prevent the spread of the bacteria to other people. [2 marks] 1 wash hands after being sick Isolation - 2 Avoid food Isolate infected person preparing - if 1 , 0 1 . 3 In very serious infections of Salmonella , a doctor can prescribe drugs to kill the bacteria. - What type of drug can the doctor prescribe to kill the bacteria? [1 mark] Antibiotics I acquired immunodeficiency syndrome § gy ← 0 1 . 4 A person with AIDS may take longer than a healthy person to recover from a Salmonella infection. Explain why. [2 marks] Immune system is damaged / weaker and white blood , cells cannot kill Salmonella effectively healthy as as in a person . Turn over ► * 03 * IB/M/Jun18/8461/1H