June 2022 QP

Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature I declare this is my own work. F GCSE BIOLOGY Foundation Tier Paper 1F Time allowed: 1 hour 45 minutes Materials For Examiner’s Use For this paper you must have: • a ruler Question Mark • a scientific calculator. 1 Instructions 2 • Use black ink or black ball-point pen. 3 • Pencil should only be used for drawing. 4 • Fill in the boxes at the top of this page. 5 • Answer all questions in the spaces provided. • If you need extra space for your answer(s), use the lined pages at the end of 6 this book. Write the question number against your answer(s). 7 • Do all rough work in this book. Cross through any work you do not want 8 to be marked. • In all calculations, show clearly how you work out your answer. TOTAL Information • The maximum mark for this paper is 100. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. * JUN2284611F01 * 8461/1F IB/M/ Jun22 /E1 8

Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature I declare this is my own work. F GCSE BIOLOGY Foundation Tier Paper 1F Time allowed: 1 hour 45 minutes Materials For this paper you must have: For Examiner’s Use • a ruler Question Mark • a scientific calculator. 1 Instructions 2 • Use black ink or black ball-point pen. 3 • Pencil should only be used for drawing. 4 • Fill in the boxes at the top of this page. 5 • Answer all questions in the spaces provided. • If you need extra space for your answer(s), use the lined pages at the end of 6 this book. Write the question number against your answer(s). 7 • Do all rough work in this book. Cross through any work you do not want 8 to be marked. • In all calculations, show clearly how you work out your answer. TOTAL Information • The maximum mark for this paper is 100. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. * JUN2284611F01 * 8461/1F IB/M/ Jun22 /E1 8

2 Do not write outside the Answer all questions in the spaces provided. box 0 1 HIV (Human Immunodeficiency Virus) is a pathogen. 0 1 . 1 How is HIV spread from one person to another person? [1 mark] Tick (  ) one box. Coughing Sexual intercourse Touching door handles Table 1 shows information about new cases of HIV diagnosed in the UK. Table 1 Year Number of new HIV cases 2010 2642 2014 2767 2018 1530 0 1 . 2 Describe what happened to the number of new cases of HIV from 2010 to 2018. [ 2 marks] * 02 * IB/M/Jun22/8461/1F

2 Do not write outside the Answer all questions in the spaces provided. box 0 1 HIV (Human Immunodeficiency Virus) is a pathogen. 0 1 . 1 How is HIV spread from one person to another person? [1 mark] Tick (  ) one box. Coughing Sexual intercourse Touching door handles Table 1 shows information about new cases of HIV diagnosed in the UK. Table 1 Year Number of new HIV cases 2010 2642 2014 2767 2018 1530 0 1 . 2 Describe what happened to the number of new cases of HIV from 2010 to 2018. [ 2 marks] * 02 * IB/M/Jun22/8461/1F

3 Do not write outside the 0 1 . 3 What could cause a decrease in the number of new HIV cases in the future ? box [1 mark] Tick (  ) one box. A higher population of people in the UK A lower number of trained HIV nurses Better education on how to prevent the spread of HIV 0 1 . 4 Scientists have been working to produce a vaccine for HIV for many years. How could a vaccine work to prevent a person being infected with HIV? Write the stages A , B , C , D and E in the correct order. [3 marks] The first stage has been completed for you. A Antibodies attach to the inactive virus. B Antibodies destroy the inactive virus. C An inactive form of the virus is injected into the body. D If the active virus enters the body, antibodies are produced quickly. E White blood cells produce antibodies to the inactive virus. Question 1 continues on the next page Turn over ► * 03 * IB/M/Jun22/8461/1F

3 Do not write outside the 0 1 . 3 What could cause a decrease in the number of new HIV cases in the future ? box [1 mark] Tick (  ) one box. A higher population of people in the UK A lower number of trained HIV nurses Better education on how to prevent the spread of HIV 0 1 . 4 Scientists have been working to produce a vaccine for HIV for many years. How could a vaccine work to prevent a person being infected with HIV? Write the stages A , B , C , D and E in the correct order. [3 marks] The first stage has been completed for you. A Antibodies attach to the inactive virus. B Antibodies destroy the inactive virus. C An inactive form of the virus is injected into the body. D If the active virus enters the body, antibodies are produced quickly. E White blood cells produce antibodies to the inactive virus. Question 1 continues on the next page Turn over ► * 03 * IB/M/Jun22/8461/1F